Background : Carotid intima-media thickness (IMT) ,carotid peak systolic velocity (PSV) and pulse wave velocity (PWV) are non-invasive predictors of future coronary artery disease (CAD). However , studies examining the association of these predictors are limited in patients with CAD and dyslipidemia.
Objective : To evaluate the correlation between carotid IMT, carotid PSV and PWV in patients with CAD and dyslipidemia.
Methods : Carotid B-mode ultrasound, Doppler flow velocity ; PSV and brachial-ankle PWV were performed in patients who had clinical suspicions of CAD and in those patients with documented dyslipidemia who underwent coronary angiography (CAG) at the Chest Disease Institute from January 2006 to September 2006.
Results : 37 patients were studied : 22 in the non-CAD group and 15 in the CAD group. No significant differences in most of the demographic data were found between the groups. The only differences found were that the CAD group was older and predominantly male with a lower heart rate, lower low density lipoprotein (LDL) and lower high density lipoprotein (HDL) . Mean carotid IMT, mean carotid PSV and mean PWV were comparable between the groups. No significant correlations between mean carotid IMT, mean carotid PSV and mean PWV were found in either group, with the exception of a correlation between mean carotid IMT and mean PWV in the non CAD group (r=0.507,p=0.016). However, the mean carotid IMT was higher in patients with 3 vessel or left main CAD than those with normal CAG (0.822 mm vs 0.548 mm;p=0.005).
Conclusion : In patients with CAD and dyslipidemia, there was no correlation between carotid IMT, carotid PSV and brachial-ankle PWV. However , the carotid IMT was significantly higher in those patients with 3 vessel or left main CAD.